SARS-CoV-2 Spike protein hijacks VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

Aubin Moutal; Laurent F. Martin; Lisa Boinon; Kimberly Gomez; Dongzhi Ran; Yuan Zhou; Harrison J. Stratton; Song Cai; Shizhen Luo; Kerry Beth Gonzalez; Samantha Perez-Miller; Amol Patwardhan; Mohab M. Ibrahim; Rajesh Khanna

doi:10.1101/2020.07.17.209288

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SARS-CoV-2 Spike protein hijacks VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

View ORCID ProfileAubin Moutal, View ORCID ProfileLaurent F. Martin, View ORCID ProfileLisa Boinon, View ORCID ProfileKimberly Gomez, View ORCID ProfileDongzhi Ran, Yuan Zhou, View ORCID ProfileHarrison J. Stratton, Song Cai, Shizhen Luo, Kerry Beth Gonzalez, View ORCID ProfileSamantha Perez-Miller, Amol Patwardhan, Mohab M. Ibrahim, View ORCID ProfileRajesh Khanna

doi: https://doi.org/10.1101/2020.07.17.209288

Aubin Moutal

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Laurent F. Martin

2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Lisa Boinon

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Kimberly Gomez

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Dongzhi Ran

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Yuan Zhou

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Harrison J. Stratton

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Song Cai

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Shizhen Luo

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Kerry Beth Gonzalez

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Samantha Perez-Miller

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Amol Patwardhan

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

4Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Mohab M. Ibrahim

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

4Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, Arizona, 85724 United States of America

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Rajesh Khanna

1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America

3Center for Innovation in Brain Sciences, University of Arizona, Tucson, Arizona 85721, United States of America

4Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, Arizona, 85724 United States of America

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For correspondence: rkhanna@arizona.edu

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SARS-CoV-2 Spike protein hijacks VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

Aubin Moutal, Laurent F. Martin, Lisa Boinon, Kimberly Gomez, Dongzhi Ran, Yuan Zhou, Harrison J. Stratton, Song Cai, Shizhen Luo, Kerry Beth Gonzalez, Samantha Perez-Miller, Amol Patwardhan, Mohab M. Ibrahim, Rajesh Khanna

bioRxiv 2020.07.17.209288; doi: https://doi.org/10.1101/2020.07.17.209288

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SARS-CoV-2 Spike protein hijacks VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

bioRxiv 2020.07.17.209288; doi: https://doi.org/10.1101/2020.07.17.209288

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