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Post-vaccination Omicron infections induce broader immunity across antigenic space than prototype mRNA COVID-19 booster vaccination or primary infection
Wei Wang, Sabrina Lusvarghi, Rahul Subramanian, Nusrat J. Epsi, Richard Wang, Emilie Goguet, Anthony C Fries, Fernando Echegaray, Russell Vassell, Si’Ana Coggins, Stephanie A. Richard, David A. Lindholm, Katrin Mende, Evan Ewers, Derek Larson, Rhonda E. Colombo, Christopher Colombo, Janet O. Joseph, Julia Rozman, Alfred Smith, Tahaniyat Lalani, Catherine Berjohn, Ryan Maves, Milissa Jones, Rupal Mody, Nikhil Huprikar, Jeffrey Livezey, David Saunders, Monique Hollis-Perry, Gregory Wang, Anuradha Ganesan, Mark P. Simons, Christopher C. Broder, David Tribble, Eric D. Laing, View ORCID ProfileBrian Agan, Timothy H. Burgess, Edward Mitre, Simon D. Pollett, Leah C. Katzelnick, Carol D. Weiss
doi: https://doi.org/10.1101/2022.07.05.498883
Wei Wang
1Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
Sabrina Lusvarghi
1Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
Rahul Subramanian
2Office of Data Science and Emerging Technologies, Office of Science Management and Operations, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Nusrat J. Epsi
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
Richard Wang
1Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
Emilie Goguet
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
5Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Anthony C Fries
6U.S. Air Force School of Aerospace Medicine, Wright-Patterson Air Force Base, OH, USA
Fernando Echegaray
7Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Russell Vassell
1Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
Si’Ana Coggins
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
5Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Stephanie A. Richard
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
David A. Lindholm
8Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, TX, USA
9Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Katrin Mende
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
Evan Ewers
10Fort Belvoir Community Hospital, Fort Belvoir, VA, USA
Derek Larson
10Fort Belvoir Community Hospital, Fort Belvoir, VA, USA
Rhonda E. Colombo
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
9Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
11Madigan Army Medical Center, Joint Base Lewis McChord, WA, USA
Christopher Colombo
9Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
11Madigan Army Medical Center, Joint Base Lewis McChord, WA, USA
Janet O. Joseph
7Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Julia Rozman
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
Alfred Smith
12Naval Medical Center Portsmouth, Portsmouth, VA, USA
Tahaniyat Lalani
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
12Naval Medical Center Portsmouth, Portsmouth, VA, USA
Catherine Berjohn
13Naval Medical Center San Diego, San Diego, CA, USA
Ryan Maves
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
9Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Milissa Jones
14Tripler Army Medical Center, Honolulu, HI, USA
Rupal Mody
15William Beaumont Army Medical Center, El Paso, TX, USA
Nikhil Huprikar
16Walter Reed National Military Medical Center, Bethesda, MD, USA
Jeffrey Livezey
17Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
David Saunders
9Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Monique Hollis-Perry
18Clinical Trials Center, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, USA
Gregory Wang
19General Dynamics Information Technology, Falls Church, VA, USA
Anuradha Ganesan
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
16Walter Reed National Military Medical Center, Bethesda, MD, USA
Mark P. Simons
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Christopher C. Broder
5Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
David Tribble
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Eric D. Laing
5Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Brian Agan
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
Timothy H. Burgess
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Edward Mitre
5Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Simon D. Pollett
3Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
4Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
Leah C. Katzelnick
7Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Carol D. Weiss
1Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
Posted July 06, 2022.
Post-vaccination Omicron infections induce broader immunity across antigenic space than prototype mRNA COVID-19 booster vaccination or primary infection
Wei Wang, Sabrina Lusvarghi, Rahul Subramanian, Nusrat J. Epsi, Richard Wang, Emilie Goguet, Anthony C Fries, Fernando Echegaray, Russell Vassell, Si’Ana Coggins, Stephanie A. Richard, David A. Lindholm, Katrin Mende, Evan Ewers, Derek Larson, Rhonda E. Colombo, Christopher Colombo, Janet O. Joseph, Julia Rozman, Alfred Smith, Tahaniyat Lalani, Catherine Berjohn, Ryan Maves, Milissa Jones, Rupal Mody, Nikhil Huprikar, Jeffrey Livezey, David Saunders, Monique Hollis-Perry, Gregory Wang, Anuradha Ganesan, Mark P. Simons, Christopher C. Broder, David Tribble, Eric D. Laing, Brian Agan, Timothy H. Burgess, Edward Mitre, Simon D. Pollett, Leah C. Katzelnick, Carol D. Weiss
bioRxiv 2022.07.05.498883; doi: https://doi.org/10.1101/2022.07.05.498883
Post-vaccination Omicron infections induce broader immunity across antigenic space than prototype mRNA COVID-19 booster vaccination or primary infection
Wei Wang, Sabrina Lusvarghi, Rahul Subramanian, Nusrat J. Epsi, Richard Wang, Emilie Goguet, Anthony C Fries, Fernando Echegaray, Russell Vassell, Si’Ana Coggins, Stephanie A. Richard, David A. Lindholm, Katrin Mende, Evan Ewers, Derek Larson, Rhonda E. Colombo, Christopher Colombo, Janet O. Joseph, Julia Rozman, Alfred Smith, Tahaniyat Lalani, Catherine Berjohn, Ryan Maves, Milissa Jones, Rupal Mody, Nikhil Huprikar, Jeffrey Livezey, David Saunders, Monique Hollis-Perry, Gregory Wang, Anuradha Ganesan, Mark P. Simons, Christopher C. Broder, David Tribble, Eric D. Laing, Brian Agan, Timothy H. Burgess, Edward Mitre, Simon D. Pollett, Leah C. Katzelnick, Carol D. Weiss
bioRxiv 2022.07.05.498883; doi: https://doi.org/10.1101/2022.07.05.498883
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